Gene Mutations and Pharmacogenetics
نویسندگان
چکیده
منابع مشابه
European attitudes to gene therapy and pharmacogenetics.
Views on pharmacogenetics and gene therapy systematically differ across European countries. But despite a complex regulatory regime there is a balance of support, albeit laced with considerable uncertainty.
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Rheumatoid arthritis (RA) is a systemic, chronic and inflammatory disease of unknown etiology with genetic predisposition. The advent of new biological agents, as well as the more traditional disease-modifying antirheumatic drugs, has resulted in highly efficient therapies for reducing the symptoms and signs of RA; however, not all patients show the same level of response in disease progression...
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Pharmacogenetics is the study of the role of inheritance in variation to drug response. Drug response phenotypes can vary from adverse drug reactions at one end of the spectrum to equally serious lack of the desired effect of drug therapy at the other. Many of the current important examples of pharmacogenetics involve inherited variation in drug metabolism. Sulfate conjugation catalyzed by cyto...
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Individualne razlike u farmakološkom odgovoru bolesnika na primenjene lekove dovode do ozbiljnih kliničkih problema, od kojih su najvažniji otežano lečenje, neželjene reakcije na lekove i interakcije među lekovima. Sve je veći broj dokaza da su zapaženi induvidualizmi u farmakokinetici i farmakodinamici lekova genetski determinisani i da primarno obuhvataju metabolizam lekova i transportne proc...
متن کاملNovel Missense Mitochondrial ND4L Gene Mutations in Friedreich's Ataxia
Objective(s) The mitochondrial defects in Friedreich's ataxia have been reported in many researches. Mitochondrial DNA is one of the candidates for defects in mitochondrion, and complex I is the first and one of the largest catalytic complexes of oxidative phosphorylation (OXPHOS) system. Materials and Methods We searched the mitochondrial ND4L gene for mutations by TTGE and sequencing on 30...
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ژورنال
عنوان ژورنال: Pharmacy & Pharmacology International Journal
سال: 2016
ISSN: 2379-6367
DOI: 10.15406/ppij.2016.04.00085